賴振宏
長庚醫療財團法人林口長庚紀念醫院
國語,英語,閩南語,客語 教授
氣喘、過敏、紅斑性狼瘡、自體免疫疾病、類風濕性關節炎、僵直性脊椎炎、痛風關節炎
賴振宏看診時間
| 星期一 | 24 小時營業 |
| 星期二 | 24 小時營業 |
| 星期三 | 24 小時營業 |
| 星期四 | 24 小時營業 |
| 星期五 | 24 小時營業 |
| 星期六 | 24 小時營業 |
| 星期日 | 24 小時營業 |
賴振宏醫師簡介
現職
- 中華民國風濕病醫學會 理事
- 林口長庚醫院 學術組 教授級 主治醫師
學歷
- 國防醫學院醫學系
- 美國醫師執照檢覈考試通過 (FMGEMS)
- 美國德州醫學中心貝勒醫學院免疫學博士
經歷
- 國防醫學院預防醫學研究所所長
- 三軍總醫院風濕過敏免疫科主任醫師
學會與認證
- Chinese Board of Allergy and Immunology
- Chinese Board of Rheumatology
- Chinese Board of Internal Medicine
- FMGEMS (Foreign Medical Graduate Examination of Medical Science, compatible with VQE, USMLE), USA
- National Board Qualification for Physicians
論文及期刊發表
- Potential therapeutic targets beyond cytokines and Janus kinases for autoimmune arthritis,
Biochem Pharmacol 213 115622. (2023).
Wu, C.Y., Yang, H.Y., Lai JH* - Ferroptosis and Autoimmune Diseases.
Front Immunol 13, 916664. (2022).
Lai, B., Wu, C.H., Wu, C.Y., Luo, S.F., and Lai JH* - Vitamin D Supplementation in Patients with Juvenile Idiopathic Arthritis.
Nutrients 14.(2022).
Wu, C.Y., Yang, H.Y., Luo, S.F., Huang, J.L., and Lai JH* - Targeting the JAK-STAT pathway in autoimmune diseases and cancers: A focus on molecular mechanisms and therapeutic potential.
Biochem Pharmacol 2021, 193, 114760, doi:10.1016/j.bcp.2021.114760.
Tzeng, H.T.; Chyuan, I.T.; Lai JH* - (2021). Signals and Mechanisms Regulating Monocyte and Macrophage Activation in the Pathogenesis of Juvenile Idiopathic Arthritis.
Int J Mol Sci 22.
Wu, C.Y., Yang, H.Y., Huang, J.L., and Lai JH* - Mitochondrial protein CMPK2 mediates immunomodulatory and antiviral activities through IFN-dependent and IFN-independent pathways.
iScience 24(6):102498. doi: 10.1016/j.isci.2021.102498.
Lai JH, Wu DW, Wu CH, Hung LF, Huang CY, Ka SM, Chen A, Chang ZF, Ho LJ. - Mitochondrial protein CMPK2 regulates IFN alpha-enhanced foam cell formation, potentially contributing to premature atherosclerosis in SLE.
Arthritis Res Ther 23(1):120. doi: 10.1186/s13075-021-02470-6.
Lai, J.H., Hung, L.F., Huang, C.Y., Wu, D.W., Wu, C.H., and Ho, L.J. (2021). - From Rheumatoid Factor to Anti-Citrullinated Protein Antibodies and Anti-Carbamylated Protein Antibodies for Diagnosis and Prognosis Prediction in Patients with Rheumatoid Arthritis.
Int J Mol Sci 22.
Wu, C.Y., Yang, H.Y., Luo, S.F., and Lai JH* - Epigallocatechin-3-gallate exhibits immunomodulatory effects in human primary T cells.
Biochem Biophys Res Commun 550, 70-76.
Huang, S.C., Kao, Y.H., Shih, S.F., Tsai, M.C., Lin, C.S., Chen, L.W., Chuang, Y.P., Tsui, P.F., Ho, L.J., Lai, J.H., et al. - Activation of c-Jun N-Terminal Kinase, a Potential Therapeutic Target in Autoimmune Arthritis.
Cells 2020;9:
Lai B, Wu CH, Lai JH*. - Anti-Citrullinated Protein Antibodies in Patients with Rheumatoid Arthritis: Biological Effects and Mechanisms of Immunopathogenesis.
Int J Mol Sci 2020;21:
Wu CY, Yang HY, Lai JH*. - New insights into the IL-12 and IL-23: From a molecular basis to clinical application in immune-mediated inflammation and cancers.
Biochem Pharmacol 2020;175:113928.
Chyuan IT, Lai JH*. - Monosodium urate crystals induced ICAM-1 expression and cell-cell adhesion in renal mesangial cells: Implications for the pathogenesis of gouty nephropathy.
J Microbiol Immunol Infect 2020;53:23-32.
Luo SF, Chin CY, Ho LJ, Tseng WY, Kuo CF, Lai JH*. - A new laboratory surrogate (Monocyte Chemotactic Protein-1) for Disease Activity Score28: a favourable indicator for remission in rheumatoid arthritis.
Sci Rep 2020;10:8238.
Liou LB, Fang YF, Tan CF, Lai JH, Jang SS, Tsai PH, et al. - Compound K inhibits priming and mitochondria-associated activating signals of NLRP3 inflammasome in renal tubulointerstitial lesions.
Nephrol Dial Transplant 2020;35:74-85.
Hsu WH, Hua KF, Tuan LH, Tsai YL, Chu LJ, Lee YC, et al. - Anti-inflammatory and anti-osteoarthritis effects of Cm-02 and Ck-02.
Biochem Biophys Res Commun 2019;517:155-163.
Ho YJ, Lu JW, Ho LJ, Lai JH, Huang HS, Lee CC, et al. - Targeting the CD40-CD154 Signaling Pathway for Treatment of Autoimmune Arthritis.
Cells 2019;8:
Lai JH*, Luo SF, Ho LJ. - Pitavastatin Exerts Potent Anti-Inflammatory and Immunomodulatory Effects via the Suppression of AP-1 Signal Transduction in Human T Cells.
Int J Mol Sci 2019;20:
Chen LW, Lin CS, Tsai MC, Shih SF, Lim ZW, Chen SJ, et al. - Useful message in choosing optimal biological agents for patients with autoimmune arthritis”
Biochem Pharmacol, 2019,165, 99-111.
Lai, J.H.*, Ling, X.C., and Ho, L.J.* - Chondroprotective Effects and Mechanisms of Dextromethorphan: Repurposing Antitussive Medication for Osteoarthritis Treatment.
Int J Mol Sci 2018;19:
Chen LW, Liu FC, Hung LF, Huang CY, Lien SB, Lin LC, et al. - Liu FC, Lu JW, Chien CY, Huang HS, Lee CC, Lien SB, et al.Similarity with Quercetin.
Int J Mol Sci 2018;19:
Arthroprotective Effects of Cf-02 Sharing Structural - Infection with the dengue RNA virus activates TLR9 signaling in human dendritic cells.
EMBO Rep 2018;19: e46182.
Lai JH, Wang MY, Huang CY, Wu CH, Hung LF, Yang CY, et al. - Operation of mitochondrial machinery in viral infection-induced immune responses.
Biochem Pharmacol 2018;156:348-356.
Lai JH, Luo SF, Ho LJ. - Hydroxychloroquine and risk of cancer in patients with primary Sjogren syndrome: propensity score matched landmark analysis.
Oncotarget 2017;8:80461-80471.
Fang YF, Chen YF, Chung TT, See LC, Yu KH, Luo SF, Kuo CF, Lai JH*. - Translational Implication of Galectin-9 in the Pathogenesis and Treatment of Viral Infection.
Int J Mol Sci 2017;18:
Lai JH*, Luo SF, Wang MY, Ho LJ. - JNK/AP-1 activation contributes to tetrandrine resistance in T-cell acute lymphoblastic leukaemia.
Acta Pharmacol Sin 2017;38:1171-1183.
Liou JT, Lin CS, Liao YC, Ho LJ, Yang SP, Lai JH*. - Physiological concentrations of soluble uric acid are chondroprotective and anti-inflammatory.
Sci Rep 2017;7:2359.
Lai JH, Luo SF, Hung LF, Huang CY, Lien SB, Lin LC, et al. - Epigallocatechin-3-gallate Reduces Scavenger Receptor A Expression and Foam Cell Formation in Human Macrophages.
J Agric Food Chem 2017;65:3141-3150.
Chen SJ, Kao YH, Jing L, Chuang YP, Wu WL, Liu ST, Huang SM, Lai JH, Ho LJ, Tsai MC, and Lin CS. - Pharmacological intervention for dengue virus infection.
Biochem Pharmacol 2017;129:14-25.
Lai JH*, Lin YL, and Hsieh SL. - Safety and efficacy of oral febuxostat for treatment of HLA-B*5801-negative gout: a randomized, open-label, multicentre, allopurinol-controlled study.
Scand J Rheumatol 2016;45:304-11.
Yu KH, Lai JH, Hsu PN, Chen DY, Chen CJ, Lin HY. - A New Application of Parallel Synthesis Strategy for Discovery of Amide-Linked Small Molecules as Potent Chondroprotective Agents in TNF-alpha-Stimulated Chondrocytes.
PLoS One 2016;11:e0149317.
Lee CC, Lo Y, Ho LJ, Lai JH, Lien SB, Lin LC, et al. - Gentiana scabra Reduces SR-A Expression and Oxidized-LDL Uptake in Human Macrophages.
Acta Cardiol Sin 2016;32:460-6.
Lin CS, Liu PY, Lian CH, Lin CH, Lai JH, Ho LJ, et al. - Dengue virus infection induces interferon-lambda1 to facilitate cell migration.
Sci Rep 2016;6:24530. doi: 10.1038/srep24530.
Hsu YL, Wang MY, Ho LJ, and Lai JH*. - Biological effects of interleukin-6: Clinical applications in autoimmune diseases and cancers.
Biochem Pharmacol 2015 (available on line June 12, 2015).
Ho LJ, Luo SF, and Lai JH*. - Up-regulation of galectin-9 induces cell migration in human dendritic cells infected with dengue virus.
J Cell Mol Med 2015 (in press).
Hsu YL, Wang MY, Ho LJ, Huang CY, and Lai JH*. - Protein kinase C isoforms in atherosclerosis: Pro- or anti-inflammatory?
Biochem Pharmacol 2014;88:139-49.
Fan HC, Fernandez-Hernando C, Lai JH*. - Differential immunomodulatory effects by Tripterygium wilfordii Hook f-derived refined extract PG27 and its purified component PG490 (triptolide) in human peripheral blood T cells: potential therapeutics for arthritis and possible mechanisms explaining in part Chinese herbal theory "Junn-Chenn-Zuou-SS".
J Transl Med 2013;11:294.
Ho LJ, Chang WL, Chen A, Chao P, Lai JH*. - Small-molecule inhibitors for autoimmune arthritis: success, failure and the future.
Eur J Pharmacol 2015 (in press).
Ho LJ, Lai JH*. - Useful biomarkers for assessment of hepatitis C virus infection-associated autoimmune disorders.
World J Gastroenterol 2014;20:2962-70.
Yang DH, Ho LJ, Lai JH*. - PKCdelta signalling regulates SR-A and CD36 expression and foam cell formation.
Cardiovasc Res 2012;95:346-55.
Lin CS, Lin FY, Ho LJ, Tsai CS, Cheng SM, Wu WL, Huang CY, Lian CH, Yang SP, Lai JH*. - Antroquinonol differentially modulates T cell activity and reduces interleukin-18 production, but enhances Nrf2 activation, in murine accelerated severe lupus nephritis.
Arthritis Rheum 2012;64:232-42.
Tsai PY, Ka SM, Chang JM, Lai JH, Dai MS, Jheng HL, Kuo MT, Chen P, Chen A. - A salicylate-based small molecule HS-Cm exhibits immunomodulatory effects and inhibits dipeptidyl peptidase-IV activity in human T cells.
Eur J Pharmacol 2014;726C:124-32.
Liou JT, Huang HS, Chiang ML, Lin CS, Yang SP, Ho LJ, Lai JH*. - Ginkgo biloba Extract Individually Inhibits JNK Activation and Induces c-Jun Degradation in Human Chondrocytes: Potential Therapeutics for Osteoarthritis.
PLoS One 2013;8:e82033.
Ho LJ, Hung LF, Liu FC, Hou TY, Lin LC, Huang CY, Lai JH*. - Protective roles of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) in dengue virus infection of human lung epithelial cells.
PLoS One 2013;8:e79518.
Hsu YL, Shi SF, Wu WL, Ho LJ, Lai JH*. - Janus kinase/signal transducer and activator of transcription 3 signaling pathway is crucial in chemokine production from hepatocytes infected by dengue virus.
Exp Biol Med (Maywood) 2011;236:1156-65.
Tsai YT, Chen YH, Chang DM, Chen PC, Lai JH*. - A Benzamide-Linked Small Molecule HS-Cf Inhibits TNF-alpha-Induced Interferon Regulatory Factor-1 in Porcine Chondrocytes: A Potential Disease-Modifying Drug for Osteoarthritis Therapeutics.
J Clin Immunol 2011;31:1131-42.
Liu FC, Huang HS, Huang CY, Yang R, Chang DM, Lai JH*, Ho LJ. - Magnesium lithospermate B mediates anti-inflammation targeting activator protein-1 and nuclear factor-kappa B signaling pathways in human peripheral T lymphocytes.
Int Immunopharmacol 2012;13:354-61.
Cheng CC, Yang SP, Lin WS, Ho LJ, Lai JH, Cheng SM, Lin WY. - Immunosuppressive Effects and Mechanisms of Leflunomide in Dengue Virus Infection of Human Dendritic Cells.
J Clin Immunol 2011;31: 1065-78.
Wu WL, Ho LJ, Chen PC, Tsai YT, Hsu ST, Chang DM, Lai JH*. - Modulation of human T cells signaling transduction by lovastatin.
Int J Cardiol 2010;140:24-33.
Cheng SM, Lai JH, Yang SP, Tsao TP, Ho LJ, Liou JT, Cheng CC. - The modulatory mechanisms of fenofibrate on human primary T cells.
Eur J Pharm Sci 2010;40:316-24.
Cheng SM, Chu KM, Lai JH. - A/H1N1 influenza vaccination in patients with systemic lupus erythematosus: safety and immunity.
Vaccine 2011;29:444-50.
Lu CC, Wang YC, Lai JH, Lee TS, Lin HT, Chang DM. - Phytoestrogen bavachin mediates anti-inflammation targeting Ikappa B kinase-I kappaB alpha-NF-kappaB signaling pathway in chondrocytes in vitro.
Eur J Pharmacol 2010;636:181-8.
Cheng CC, Chen YH, Chang WL, Yang SP, Chang DM, Lai JH*, Ho LJ. - A spontaneous intercostal artery hemorrhage in systemic lupus erythematosus.
Rheumatol Int 2012;32:829-31.
Lu CC, Chen CH, Yeh SF, Lai JH, Chang DM. - Remitting seronegative symmetrical synovitis with pitting edema following acute intracranial hemorrhage.
Rheumatol Int 2011;31:101-4.
Yang DH, Chang DM, Lai JH, Huang GS, Chang WC, Hou TY. - Peripheral arthritis caused by Mycobacterium avium-intracellulare in a patient with ankylosing spondylitis.
J Clin Rheumatol 2009;15:323-4.
Yang DH, Chang WC, Cheng MF, Lai JH, Chang DM, Chen CH. - Usefulness of erythrocyte-bound C4d as a biomarker to predict disease activity in patients with systemic lupus erythematosus.
Rheumatology (Oxford) 2009;48:1083-7.
Yang DH, Chang DM, Lai JH, Lin FH, Chen CH. - Significantly higher percentage of circulating CD27(high) plasma cells in systemic lupus erythematosus patients with infection than with disease flare-up.
Yonsei Med J 2010;51:924-31.
Yang DH, Chang DM, Lai JH, Lin FH, Chen CH. - Chondroprotective effects and mechanisms of resveratrol in advanced glycation end products-stimulated chondrocytes.
Arthritis Res Ther 2010;12:R167.
Liu FC, Hung LF, Wu WL, Chang DM, Huang CY, Lai JH*, Ho LJ. - Triggering of DC migration by dengue virus stimulation of COX-2-dependent signaling cascades in vitro highlights the significance of these cascades beyond inflammation.
Eur J Immunol 2009;39:3413-22.
Wu WL, Ho LJ, Chang DM, Chen CH, Lai JH*. - Etanercept as a rescue agent in patient with adult onset Still's disease complicated with congestive heart failure.
Rheumatol Int 2008;29:95-8.
Yang DH, Chang DM, Lai JH, Kuo SY, Ho TY, Lin KM, Chen CH. - Suppression of tissue necrosis factor-alpha or hydrogen peroxide-activated primary human T lymphocytes by Ginkgo biloba extract through down-regulation of activator protein-1 signal transduction.
Phytomedicine 2008;15:170-6.
Tsao TP, Lai JH, Yang SP, Ho LJ, Liou JT, Cheng CC, Cheng SM. - Acupuncture-associated Listeria monocytogenes arthritis in a patient with rheumatoid arthritis.
Joint Bone Spine 2008;75:502-3.
Tien CH, Huang GS, Chang CC, Chang DM, Lai JH*. - Usefulness of anti-CCP antibodies in patients with hepatitis C virus infection with or without arthritis, rheumatoid factor, or cryoglobulinemia.
Clin Rheumatol 2008;27:463-7.
Liu FC, Chao YC, Hou TY, Chen HC, Shyu RY, Hsieh TY, Chen CH, Chang DM, Lai JH*. - Differential effects of triptolide and tetrandrine on activation of COX-2, NF-kappaB, and AP-1 and virus production in dengue virus-infected human lung cells.
Eur J Pharmacol 2008;589:288-98.
Liou JT, Chen ZY, Ho LJ, Yang SP, Chang DM, Liang CC, Lai JH*. - Formation of numerous rice bodies: an unusual finding of adult-onset Still's disease.
Clin Rheumatol 2008;27 Suppl 2:S55-7.
Lin KM, Lai JH, Chang CC, Lin CK, Chang DM, Chen CH. - Retinoid acid inhibits IL-1-induced iNOS, COX-2 and chemokine production in human chondrocytes.
Immunol Invest 2008;37:675-93.
Hung LF, Lai JH, Lin LC, Wang SJ, Hou TY, Chang DM, Liang CC, Ho LJ. - Interleukin (IL)-23 p19 expression induced by IL-1beta in human fibroblast-like synoviocytes with rheumatoid arthritis via active nuclear factor-kappaB and AP-1 dependent pathway.
Rheumatology (Oxford) 2007;46:1266-73.
Liu FL, Chen CH, Chu SJ, Chen JH, Lai JH, Sytwu HK, Chang DM. - Purtscher's-like retinopathy as an initial presentation of adult-onset Still's disease: a case report and review of the literature.
Clin Rheumatol 2007;26:1204-6.
Liu FC, Chiang SY, Chang DM, Lai JH, Hou TY, Chen CH. - Autoimmune hepatitis with raised alpha-fetoprotein level as the presenting symptoms of systemic lupus erythematosus: a case report.
Rheumatol Int 2007;27:489-91.
Liu FC, Chang DM, Lai JH, Lin CK, Chen HC, Hou TY, Kuo SY. - Usefulness of human leucocyte antigen-B27 subtypes in predicting ankylosing spondylitis: Taiwan experience.
Intern Med J 2007;37:749-52.
Hou TY, Chen HC, Chen CH, Chang DM, Liu FC, Lai JH*. - Activin A suppresses interleukin-1-induced matrix metalloproteinase 3 secretion in human chondrosarcoma cells.
Rheumatol Int 2007;27:1049-55.
Chang DM, Liu SH, Lee HS, Lai JH, Chen CH. - Thymoma and hypogammaglobulinemia (Good's syndrome): a case report.
J Microbiol Immunol Infect 2005;38:218-20.
Tsai YG, Lai JH, Kuo SY, Chen HC, Chang DM. - Taiwan experience with etanercept in juvenile rheumatoid arthritis.
J Microbiol Immunol Infect 2005;38:451-4.
Lai JH*. - Sweet's syndrome as an initial presentation in systemic lupus erythematosus: a case report and review of the literature.
Lupus 2005;14:399-402.
Hou TY, Chang DM, Gao HW, Chen CH, Chen HC, Lai JH*. - Retinoic acid blocks pro-inflammatory cytokine-induced matrix metalloproteinase production by down-regulating JNK-AP-1 signaling in human chondrocytes.
Biochem Pharmacol 2005;70:200-8.
Ho LJ, Lin LC, Hung LF, Wang SJ, Lee CH, Chang DM, Lai JH*, Tai TY. - Dengue virus type 2 antagonizes IFN-alpha but not IFN-gamma antiviral effect via down-regulating Tyk2-STAT signaling in the human dendritic cell.
J Immunol 2005;174:8163-72.
Ho LJ, Hung LF, Weng CY, Wu WL, Chou P, Lin YL, Chang DM, Tai TY, Lai JH*. - Systemic lupus erythematosus with simultaneous onset of Kikuchi-Fujimoto's disease complicated with antiphospholipid antibody syndrome: a case report and review of the literature.
Rheumatol Int 2005;25:303-6.
Chen HC, Lai JH, Huang GS, Gao HW, Chen CH, Kuo SY, Chang DM. - Immunosuppressive iridoids from the fruits of Gardenia jasminoides.
J Nat Prod 2005;68:1683-5.
Chang WL, Wang HY, Shi LS, Lai JH, Lin HC. - Carvedilol differentially regulates cytokine production from activated human peripheral blood mononuclear cells.
Cardiovasc Drugs Ther 2004;18:183-8.
Yang SP, Ho LJ, Cheng SM, Hsu YL, Tsao TP, Chang DM, Lai JH*. - An unrecognized cause of oedema in a patient with lupus nephritis: protein losing enteropathy.
Nephrol Dial Transplant 2004;19:2149-50.
Wu CC, Lin SH, Chu P, Lai JH, Chang DM, Lin YF. - Infection of human dendritic cells by dengue virus activates and primes T cells towards Th0-like phenotype producing both Th1 and Th2 cytokines.
Immunol Invest 2004;33:423-37.
Ho LJ, Shaio MF, Chang DM, Liao CL, Lai JH*. - Chinese herbs as immunomodulators and potential disease-modifying antirheumatic drugs in autoimmune disorders.
Curr Drug Metab 2004;5:181-92.
Ho LJ, Lai JH*. - Plant alkaloid tetrandrine downregulates IkappaBalpha kinases-IkappaBalpha-NF-kappaB signaling pathway in human peripheral blood T cell.
Br J Pharmacol 2004;143:919-27.
Ho LJ, Juan TY, Chao P, Wu WL, Chang DM, Chang SY, Lai JH*. - Irbesartan inhibits human T-lymphocyte activation through downregulation of activator protein-1.
Br J Pharmacol 2004;142:933-42.
Cheng SM, Yang SP, Ho LJ, Tsao TP, Chang DM, Lai JH*. - Pleural effusion as a manifestation of Lyme disease.
J Rheumatol 2004;31:811-3.
Chen HC, Shih CM, Lai JH, Chao LL, Kuo SY, Chang DM. - Longitudinal myelitis as an initial manifestation of systemic lupus erythematosus.
Am J Med Sci 2004;327:105-8.
Chen HC, Lai JH, Juan CJ, Kuo SY, Chen CH, Chang DM. - Neutrophilic panniculitis with myelodysplastic syndromes presenting as pustulosis: case report and review of the literature.
Am J Hematol 2004;76:61-5.
Chen HC, Kao WY, Chang DM, Gao HW, Lai WY, Lai JH*. - Dual biological functions of an interleukin-1 receptor antagonist-interleukin-10 fusion protein and its suppressive effects on joint inflammation.
Immunology 2004;112:643-50.
Chang DM, Shyue SK, Liu SH, Chen YT, Yeh CY, Lai JH, Lee HS, Chen A. - Dehydroepiandrosterone suppresses interleukin 10 synthesis in women with systemic lupus erythematosus.
Ann Rheum Dis 2004;63:1623-6.
Chang DM, Chu SJ, Chen HC, Kuo SY, Lai JH. - The pharmacokinetics of interleukin-1 receptor antagonist in Chinese subjects with rheumatoid arthritis.
Pharmacol Res 2004;50:371-6.
Chang DM, Chang SY, Yeh MK, Lai JH. - Carvedilol, a new antioxidative beta-blocker, blocks in vitro human peripheral blood T cell activation by downregulating NF-kappaB activity.
Cardiovasc Res 2003;59:776-87.
Yang SP, Ho LJ, Lin YL, Cheng SM, Tsao TP, Chang DM, Hsu YL, Shih CY, Juan TY, Lai JH*. - Ruptured renal microaneurysms complicated with a retroperitoneal abscess for a patient with systemic lupus erythematosus.
Lupus 2003;12:317-20.
Tsai YG, Lai JH, Kuo SY, Chen HC, Wan HL, Chang DM. - Relationship between human lymphocyte antigen-B27 and clinical features of psoriatic arthritis.
J Microbiol Immunol Infect 2003;36:101-4.
Tsai YG, Chang DM, Kuo SY, Wang WM, Chen YC, Lai JH*. - Down-regulation of c-jun N-terminal kinase-activator protein-1 signaling pathway by Ginkgo biloba extract in human peripheral blood T cells.
Biochem Pharmacol 2003;66:679-89.
Cheng SM, Yang SP, Ho LJ, Tsao TP, Juan TY, Chang DM, Chang SY, Lai JH*. - Carvedilol modulates in-vitro granulocyte-macrophage colony-stimulating factor-induced interleukin-10 production in U937 cells and human monocytes.
Immunol Invest 2003;32:43-58.
Cheng SM, Yang SP, Ho LJ, Tsao TP, Chang DM, Lai JH*. - Immunosuppressive flavones and lignans from Bupleurum scorzonerifolium.
Phytochemistry 2003;64:1375-9.
Chang WL, Chiu LW, Lai JH, Lin HC. - Prognostic factors and fetal outcomes of lupus pregnancy in Taiwan.
Clin Exp Rheumatol 2003;21:798.
Chang DM, Wu YL, Chu SJ, Lai JH. - Immunomodulatory effects and mechanisms of plant alkaloid tetrandrine in autoimmune diseases.
Acta Pharmacol Sin 2002;23:1093-101.
Lai JH*. - Western and Chinese antirheumatic drug-induced T cell apoptotic DNA damage uses different caspase cascades and is independent of Fas/Fas ligand interaction.
J Immunol 2001;166:6914-24.
Lai JH*, Ho LJ, Lu KC, Chang DM, Shaio MF, Han SH. - Infection of human dendritic cells by dengue virus causes cell maturation and cytokine production.
J Immunol 2001;166:1499-506.
Ho LJ, Wang JJ, Shaio MF, Kao CL, Chang DM, Han SW, Lai JH*. - Aspirin differentially regulates endotoxin-induced IL-12 and TNF-alpha production in human dendritic cells.
Scand J Rheumatol 2001;30:346-52.
Ho LJ, Chang DM, Shiau HY, Chen CH, Hsieh TY, Hsu YL, Wong CS, Lai JH*. - Plant alkaloid tetrandrine and its analog block CD28-costimulated activities of human peripheral blood T cells: potential immunosuppressants in transplantation immunology.
Transplantation 1999;68:1383-92.
Lai JH*, Ho LJ, Kwan CY, Chang DM, Lee TC. - Plant alkaloid tetrandrine downregulates protein kinase C-dependent signaling pathway in T cells.
Eur J Pharmacol 1999;367:389-98.
Ho LJ, Chang DM, Lee TC, Chang ML, Lai JH*. - Mechanism of immunosuppression of the antirheumatic herb TWHf in human T cells.
J Rheumatol 1999;26:14-24.
Ho LJ, Chang DM, Chang ML, Kuo SY, Lai JH*. - Cell surface markers and circulating cytokines in graft versus host disease.
Immunol Invest 1999;28:77-86.
Chang DM, Wang CJ, Kuo SY, Lai JH. - Effects of anti-rheumatic herbal medicines on cellular adhesion molecules.
Ann Rheum Dis 1999;58:366-71.
Chang DM, Kuo SY, Lai JH, Chang ML. - RelA is a potent transcriptional activator of the CD28 response element within the interleukin 2 promoter.
Mol Cell Biol 1995;15:4260-71.
Lai JH, Horvath G, Subleski J, Bruder J, Ghosh P, Tan TH. - Mechanisms of enhanced nuclear translocation of the transcription factors c-Rel and NF-kappa B by CD28 costimulation in human T lymphocytes.
Ann N Y Acad Sci 1995;766:220-3.
Lai JH, Horvath G, Li Y, Tan TH. - CD28 signaling causes a sustained down-regulation of I kappa B alpha which can be prevented by the immunosuppressant rapamycin.
J Biol Chem 1994;269:30077-80.
Lai JH, Tan TH. - Effect of CD28 signal transduction on c-Rel in human peripheral blood T cells.
Mol Cell Biol 1994;14:7933-42.
Bryan RG, Li Y, Lai JH, Van M, Rice NR, Rich RR, Tan TH. - Intercostal arteriovenous fistula due to pleural biopsy.
Thorax 1991;46:400.
Tariq SM, McConnochie K, Lai JH, Kao SJ, Lee SC, Shen CY. - Intercostal arteriovenous fistula due to pleural biopsy.
Thorax 1990;45:976-8.
Lai JH, Yan HC, Kao SJ, Lee SC, Shen CY.